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The Miracle of Vitamin D PDF Print E-mail
Written by Krispin Sullivan, CN   
Sunday, 31 December 2000 00:10

Read this article in: Dutch


Notes:

In April of 2000 a clinical observation published in Archives of Internal Medicine caught my attention. Dr. Anu Prabhala and his colleagues reported on the treatment of five patients confined to wheelchairs with severe weakness and fatigue. Blood tests revealed that all suffered from severe vitamin D deficiency. The patients received 50,000 IU vitamin D per week and all became mobile within six weeks.1

Dr. Prabhala's research sparked my interest and led to a search for current information on vitamin D, how it works, how much we really need and how we get it. The following is a small part of the important information that I found.

Any discussion of vitamin D must begin with the discoveries of the Canadian-born dentist Weston A. Price. In his masterpiece Nutrition and Physical Degeneration, Dr. Price noted that the diet of isolated, so-called "primitive" peoples contained "at least ten times" the amount of "fat-soluble vitamins" as the standard American diet of his day.2 Dr. Price determined that it was the presence of plentiful amounts of fat-soluble vitamins A and D in the diet, along with calcium, phosphorus and other minerals, that conferred such high immunity to tooth decay and resistance to disease in nonindustrialized population groups.

Today another Canadian researcher, Dr. Reinhold Vieth, argues convincingly that current vitamin D recommendations are woefully inadequate. The recommended dose of 200-400 international units (IU) will prevent rickets in children but does not come close to the optimum amount necessary for vibrant health.3 According to Dr. Vieth, the minimal daily requirement of vitamin D should be in the range of 4,000 IU from all sources, rather than the 200-400 currently suggested, or ten times the Recommended Daily Allowance (RDA). Dr. Vieth's research perfectly matches Dr. Price's observations of sixty years ago!

Vitamin D From Sunlight

Pick up any popular book on vitamins and you will read that ten minutes of daily exposure of the arms and legs to sunlight will supply us with all the vitamin D that we need. Humans do indeed manufacture vitamin D from cholesterol by the action of sunlight on the skin but it is actually very difficult to obtain even a minimal amount of vitamin D with a brief foray into the sunlight.4,5

Ultraviolet (UV) light is divided into 3 bands or wavelength ranges, which are referred to as UV-C, UV-B and UV-A.6 UV-C is the most energetic and shortest of the UV bands. It will burn human skin rapidly in extremely small doses. Fortunately, it is completely absorbed by the ozone layer. However, UV-C is present in some lights. For this reason, fluorescent and halogen and other specialty lights may contribute to skin cancer.

UV-A, known as the "tanning ray," is primarily responsible for darkening the pigment in our skin. Most tanning bulbs have a high UV-A output, with a small percentage of UV-B. UV-A is less energetic than UV-B, so exposure to UV-A will not result in a burn, unless the skin is photosensitive or excessive doses are used. UV-A penetrates more deeply into the skin than UV-B, due to its longer wavelength. Until recently, UV-A was not blocked by sunscreens. It is now considered to be a major contributor to the high incidence of non-melanoma skin cancers.7 Seventy-eight percent of UV-A penetrates glass so windows do not offer protection.

The ultraviolet wavelength that stimulates our bodies to produce vitamin D is UV-B. It is sometimes called the "burning ray" because it is the primary cause of sunburn (erythema). However, UV-B initiates beneficial responses, stimulating the production of vitamin D that the body uses in many important processes. Although UV-B causes sunburn, it also causes special skin cells called melanocytes to produce melanin, which is protective. UV-B also stimulates the production of Melanocyte Stimulating Hormone (MSH), an important hormone in weight loss and energy production.8

The reason it is difficult to get adequate vitamin D from sunlight is that while UV-A is present throughout the day, the amount of UV-B present has to do with the angle of the sun's rays. Thus, UV-B is present only during midday hours at higher latitudes, and only with significant intensity in temperate or tropical latitudes. Only 5 percent of the UV-B light range goes through glass and it does not penetrate clouds, smog or fog.

Sun exposure at higher latitudes before 10 am or after 2 pm will cause burning from UV-A before it will supply adequate vitamin D from UV-B. This finding may surprise you, as it did the researchers. It means that sunning must occur between the hours we have been told to avoid. Only sunning between 10 am and 2 pm during summer months (or winter months in southern latitudes) for 20-120 minutes, depending on skin type and color, will form adequate vitamin D before burning occurs.9

It takes about 24 hours for UV-B-stimulated vitamin D to show up as maximum levels of vitamin D in the blood. Cholesterol-containing body oils are critical to this absorption process.10 Because the body needs 30-60 minutes to absorb these vitamin-D-containing oils, it is best to delay showering or bathing for one hour after exposure. The skin oils in which vitamin D is produced can also be removed by chlorine in swimming pools.

The current suggested exposure of hands, face and arms for 10-20 minutes, three times a week, provides only 200-400 IU of vitamin D each time or an average of 100-200 IU per day during the summer months. In order to achieve optimal levels of vitamin D, 85 percent of body surface needs exposure to prime midday sun. (About 100-200 IU of vitamin D is produced for each 5 percent of body surface exposed, we want 4,000 iu.) Light skinned people need 10-20 minutes of exposure while dark skinned people need 90-120 minutes.11

Latitude and altitude determine the intensity of UV light. UV-B is stronger at higher altitudes. Latitudes higher than 30° (both north and south) have insufficient UV-B sunlight two to six months of the year, even at midday.12 Latitudes higher than 40° have insufficient sunlight to achieve optimum levels of D during six to eight months of the year. In much of the US, which is between 30° and 45° latitude, six months or more during each year have insufficient UV-B sunlight to produce optimal D levels. In far northern or southern locations, latitudes 45° and higher, even summer sun is too weak to provide optimum levels of vitamin D.13-15 A simple meter is available to determine UV-B levels where you live.

Vitamin D From Food

What the research on vitamin D tells us is that unless you are a fisherman, farmer, or otherwise outdoors and exposed regularly to sunlight, living in your ancestral latitude (more on this later), you are unlikely to obtain adequate amounts of vitamin D from the sun. Historically the balance of one's daily need was provided by food. Primitive peoples instinctively chose vitamin-D-rich foods including the intestines, organ meats, skin and fat from certain land animals, as well as shellfish, oily fish and insects. Many of these foods are unacceptable to the modern palate.

For food sources to provide us with D the source must be sunlight exposed. With exposure to UV-B sunlight, vitamin D is produced from fat in the fur, feathers, and skin of animals, birds and reptiles. Carnivores get additional D from the tissues and organs of their prey. Lichen contains vitamin D and may provide a source of vitamin D in the UV-B sunlight-poor northern latitudes.16 Vitamin D content will vary in the organs and tissues of animals, pigs, cows, and sheep, depending on the amount of time spent in UV-B containing sunlight and/or how much D is given as a supplement. Poultry and eggs contain varying amounts of vitamin D obtained from insects, fishmeal, and sunlight containing UV-B or supplements. Fish, unlike mammals, birds and reptiles, do not respond to sunlight and rely on vitamin D found in phytoplankton and other fish. Salmon must feed on phytoplankton and fish in order to obtain and store significant vitamin D in their fat, flesh, skin, and organs. Thus, modern farm-raised salmon, unless artificially supplemented, may be a poor source of this essential nutrient.

Modern diets usually do not provide adequate amounts of vitamin D;17 partly because of the trend to low fat foods and partly because we no longer eat vitamin-D-rich foods like naturally reared poultry and fatty fish such as kippers, and herring. Often we are advised to consume the egg white while the D is in the yolk or we eat the flesh of the fish avoiding the D containing skin, organs and fat. Sun avoidance combined with reduction in food sources contribute to escalating D deficiencies. Vegetarian and vegan diets are exceptionally poor or completely lacking in vitamin D predisposing to an absolute need for UV-B sunlight. Using food as one's primary source of D is difficult to impossible.

Vitamin D Miracles

Sunlight and vitamin D are critical to all life forms. Standard textbooks state that the principal function of vitamin D is to promote calcium absorption in the gut and calcium transfer across cell membranes, thus contributing to strong bones and a calm, contented nervous system. It is also well recognized that vitamin D aids in the absorption of magnesium, iron and zinc, as well as calcium.

Actually, vitamin D does not in itself promote healthy bone. Vitamin D controls the levels of calcium in the blood. If there is not enough calcium in the diet, then it will be drawn from the bone. High levels of vitamin D (from the diet or from sunlight) will actually demineralize bone if sufficient calcium is not present.

Vitamin D will also enhance the uptake of toxic metals like lead, cadmium, aluminum and strontium if calcium, magnesium and phosphorus are not present in adequate amounts.18 Vitamin D supplementation should never be suggested unless calcium intake is sufficient or supplemented at the same time.

Receptors for vitamin D are found in most of the cells in the body and research during the 1980s suggested that vitamin D contributed to a healthy immune system, promoted muscle strength, regulated the maturation process and contributed to hormone production.

During the last ten years, researchers have made a number of exciting discoveries about vitamin D. They have ascertained, for example, that vitamin D is an antioxidant that is a more effective antioxidant than vitamin E in reducing lipid peroxidation and increasing enzymes that protect against oxidation.19;20

Vitamin D deficiency decreases biosynthesis and release of insulin.21 Glucose intolerance has been inversely associated with the concentration of vitamin D in the blood. Thus, vitamin D may protect against both Type I and Type II diabetes.22

The risk of senile cataract is reduced in persons with optimal levels of D and carotenoids.23

PCOS (Polycystic Ovarian Syndrome) has been corrected by supplementation of D and calcium.24

Vitamin D plays a role in regulation of both the "infectious" immune system and the "inflammatory" immune system.25

Low vitamin D is associated with several autoimmune diseases including multiple sclerosis, Sjogren's Syndrome, rheumatoid arthritis, thyroiditis and Crohn's disease.26;27

Osteoporosis is strongly associated with low vitamin D. Postmenopausal women with osteoporosis respond favorably (and rapidly) to higher levels of D plus calcium and magnesium.28

D deficiency has been mistaken for fibromyalgia, chronic fatigue or peripheral neuropathy.1;28-30

Infertility is associated with low vitamin D.31 Vitamin D supports production of estrogen in men and women.32 PMS has been completely reversed by addition of calcium, magnesium and vitamin D.33 Menstrual migraine is associated with low levels of vitamin D and calcium.81

Breast, prostate, skin and colon cancer have a strong association with low levels of D and lack of sunlight.34-38

Activated vitamin D in the adrenal gland regulates tyrosine hydroxylase, the rate limiting enzyme necessary for the production of dopamine, epinephrine and norepinephrine. Low D may contribute to chronic fatigue and depression.39

Seasonal Affective Disorder has been treated successfully with vitamin D. In a recent study covering 30 days of treatment comparing vitamin D supplementation with two-hour daily use of light boxes, depression completely resolved in the D group but not in the light box group.40

High stress may increase the need for vitamin D or UV-B sunlight and calcium.41

People with Parkinsons and Alzheimers have been found to have lower levels of vitamin D.42;43

Low levels of D, and perhaps calcium, in a pregnant mother and later in the child may be the contributing cause of "crooked teeth" and myopia. When these conditions are found in succeeding generations it means the genetics require higher levels of one or both nutrients to optimize health.44-47

Behavior and learning disorders respond well to D and/or calcium combined with an adequate diet and trace minerals.48;49

Vitamin D and Heart Disease

Research suggests that low levels of vitamin D may contribute to or be a cause of syndrome X with associated hypertension, obesity, diabetes and heart disease.50 Vitamin D regulates vitamin-D-binding proteins and some calcium-binding proteins, which are responsible for carrying calcium to the "right location" and protecting cells from damage by free calcium.51 Thus, high dietary levels of calcium, when D is insufficient, may contribute to calcification of the arteries, joints, kidney and perhaps even the brain.52-54

Many researchers have postulated that vitamin D deficiency leads to the deposition of calcium in the arteries and hence atherosclerosis, noting that northern countries have higher levels of cardiovascular disease and that more heart attacks occur in winter months.55-56

Scottish researchers found that calcium levels in the hair inversely correlated with arterial calcium—the more calcium or plaque in the arteries, the less calcium in the hair. Ninety percent of men experiencing myocardial infarction had low hair calcium. When vitamin D was administered, the amount of calcium in the beard went up and this rise continued as long as vitamin D was consumed. Almost immediately after stopping supplementation, however, beard calcium fell to pre-supplement levels.27

Administration of dietary vitamin D or UV-B treatment has been shown to lower blood pressure, restore insulin sensitivity and lower cholesterol.58-60

The Battle of the Bulge

Did you ever wonder why some people can eat all they want and not get fat, while others are constantly battling extra pounds? The answer may have to do with vitamin D and calcium status. Sunlight, UV-B, and vitamin D normalize food intake and normalize blood sugar. Weight normalization is associated with higher levels of vitamin D and adequate calcium.61 Obesity is associated with vitamin-D deficiency.62-64 In fact, obese persons have impaired production of UV-B-stimulated D and impaired absorption of food source and supplemental D.65

When the diet lacks calcium, whether from D or calcium deficiency, there is an increase in fatty acid synthase, an enzyme that converts calories into fat. Higher levels of calcium with adequate vitamin D inhibit fatty acid synthase while diets low in calcium increase fatty acid synthase by as much as five-fold. In one study, genetically obese rats lost 60 percent of their body fat in six weeks on a diet that had moderate calorie reduction but was high in calcium. All rats supplemented with calcium showed increased body temperature indicating a shift from calorie storage to calorie burning (thermogenesis).61

The Right Fats

The assimilation and utilization of vitamin D is influenced by the kinds of fats we consume. Increasing levels of both polyunsaturated and monounsaturated fatty acids in the diet decrease the binding of vitamin D to D-binding proteins. Saturated fats, the kind found in butter, tallow and coconut oil, do not have this effect. Nor do the omega-3 fats.66 D-binding proteins are key to local and peripheral actions of vitamin D. This is an important consideration as Americans have dramatically increased their intake of polyunsaturated oils (from commercial vegetable oils) and monounsaturated oils (from olive oil and canola oil) and decreased their intake of saturated fats over the past 100 years.

In traditional diets, saturated fats supplied varying amounts of vitamin D. Thus, both reduction of saturated fats and increase of polyunsaturated and monounsaturated fats contribute to the current widespread D deficiency.

Trans fatty acids, found in margarine and shortenings used in most commercial baked goods, should always be avoided. There is evidence that these fats can interfere with the enzyme systems the body uses to convert vitamin D in the liver.80

Vitamin D Therapy

In my clinical practice, I test for vitamin-D status first. If D is needed, I try to combine sunlight exposure with vitamin D and mineral supplements.

Single, infrequent, intense, skin exposure to UV-B light not only causes sunburn but also suppresses the immune system. On the other hand, frequent low-level exposure normalizes immune function, enhancing NK-cell and T-cell production, reducing abnormal inflammatory responses typical of autoimmune disorders, and reducing occurrences of infectious disease.26;67;68-71 Thus it is important to sunbathe frequently for short periods of time, when UV-B is present, rather than spend long hours in the sun at infrequent intervals. Adequate UV-B exposure and vitamin-D production can be achieved in less time than it takes to cause any redness in the skin. It is never necessary to burn or tan to obtain sufficient vitamin D.

If sunlight is not available in your area because of latitude or season, sunlamps made by Sperti can be used to provide a natural balance of UV-B and UV-A. Used according to instructions, these lamps provide a safe equivalent of sunlight and will not cause burning or even heavy tanning. Tanning beds, on the other hand, are not acceptable as a means of getting your daily dose of vitamin D because they provide high levels of UV-A and very little UV-B.

If you have symptoms of vitamin-D insufficiency or are unable to spend time in the sun, due to season or lifestyle or prior skin cancer, consider adding a supplement of 1,000 IU daily. Higher levels may be needed but should be recommended and monitored by your health care practitioner after testing serum 25(OH)D. 1,000 iu can be obtained from a concentrated supplement or from 2 teaspoons of high quality cod liver oil. Both Carlson Labs and Solgar make a 1,000 IU vitamin-D supplement naturally derived from fish oil. (Do not attempt to obtain large amounts of vitamin D from cod liver oil alone, as this would supply vitamin A in excessive and possibly toxic amounts.)

Supplementation is safe as long as sarcoidosis, liver or kidney disease is not present and the diet contains adequate calcium, magnesium and other minerals.

Adequate calcium and magnesium, as well as other minerals, are critical parts of vitamin D therapy. Without calcium and magnesium in sufficient quantities, vitamin-D supplementation will withdraw calcium from the bone and will allow the uptake of toxic minerals. Do not supplement vitamin D and do not sunbathe unless you are sure you have sufficient calcium and magnesium to meet your daily needs. Weston Price suggested a minimum of 1,200-2,400 mg of calcium daily. Research suggests that 1,200-1,500 mg is adequate as a supplement for most adults, both men and women. (Magnesium intake should be half that of calcium.)

Two excellent sources of calcium in the human diet are dairy products and bone broths.2 If the diet does not contain sufficient amounts, you will need to add supplements. Bone meal, dolomite powder or calcium and magnesium tablets (Solgar or Kal), or calcium carbonate or lactate (Solgar, Kal, Now or Twinlab) are good calcium sources, inexpensive and safe.74 All of these brands have been tested and found to be free of lead and other heavy metals.

In my experience, the forms of calcium given in supplements should be equivalent to those found in food—bone meal as in the broth, calcium lactate as in milk products and dolomite as in lime used to process cornmeal products. These forms work most efficiently and with the least cost for bone repletion and general repletion of serum calcium status.75 If your diet is high in protein, calcium lactate or carbonate is probably a better source of calcium.

Read the label carefully to see how much elemental calcium is contained in each dose or tablet and make sure to take the right amount. If the label says a serving size is three tablets and contains 1,000 mg of calcium, you must take the full serving size to get that amount.

Higher amounts of calcium are important for anyone diagnosed with bone loss. Total daily calcium as a supplement may range from 1,500 mg to 2,000 mg depending on current bone status and your body size. Make the effort to split up your daily dose. Do not take all your calcium and magnesium once a day. A higher percentage of the calcium dose is absorbed if delivered in smaller, more frequent amounts.82

Expensive "chelated" calciums are not necessary if vitamin-D status is adequate. Taking calcium without sufficient D may cause other problems. Vitamin D controls the production of some calcium binding proteins, which are critical to normal calcium utilization.

Patients on vitamin-D therapy report a wide range of beneficial results including increased energy and strength, resolution of hormonal problems, weight loss, an end to sugar cravings, blood sugar normalization and improvement of nervous system disorders.

A paradoxical transient and non-complicating hypercalciuria (more calcium in the urine) may occur when the program is first initiated. This resolves quickly when adequate calcium and other minerals are consumed. Two other temporary side effects may occur during the first several months of treatment. One is daytime sleepiness after calcium is taken. This usually resolves itself after about one week. The other condition is the reappearance of pain and discomfort at the site of old injuries, a sign of injury remodeling or proper healing, which may take some time to clear up.

Toxicity Issues

Vitamin programs usually omit vitamin D because of concerns about toxicity. These concerns are valid because vitamin D in all forms can be toxic in pharmacological (drug-like) doses. The dangers of toxicity have not been exaggerated, but the doses needed to result in toxicity have been ill defined with the unfortunate result that many people currently suffer from vitamin-D deficiency or insufficiency.

Abnormally high levels of vitamin D are indicated by blood levels exceeding 65 ng/ml or 162 nmol/l for extended periods of time and may be associated with chronic toxicity. Levels of 200-300 nmol/l or higher have been seen in several studies using supplementation and quickly resolve when supplementation is stopped. In such cases no long-term problems have been found. Long-term supplementation, without monitoring, may have serious consequences.

Before 1993, there was no affordable and available blood test for vitamin D. Now there is. To avoid problems, anyone engaging in levels of vitamin-D supplementation above 1,000 iu daily should have periodic blood tests. Don't forget to calculate your total vitamin-D intake from all sources—sunlight, food (including vitamin D in milk) and supplements, including cod liver oil.

Dr. Vieth suggests that critical toxicity may occur at doses of 20,000 IU daily and that the Upper Limit (UL) of safety be set at 10,000 IU, rather than the current 2,000 IU. While this may or may not be the definitive marker for safety in healthy persons with no active liver or kidney disease, there is no clinical evidence that long-term supplementation needs to be greater than 4,000 IU for optimal daily maintenance. This level would be somewhat lower when combined with exposure to UV-B.3;76

Doses used in clinical studies range from as little as 400 IU daily to 10,000-500,000 IU, given either as a single onetime dose or daily, weekly or monthly. Such large doses are given either as a prophylactic or because compliance is considered a problem. There seems to be some evidence that vitamin D works better, without toxicity, when given in lower, more physiologic doses of 2,000-4,000 IU daily rather than as 100,000 IU once a month. However, a single monthly dose of 100,000 IU did replete low levels of vitamin D in adolescents during winter.77

In my experience and that of other researchers, high, infrequent dosing can lead to problems. In one recent study, blood levels rose from low to extremely high, (more than 300 nmol/l) 2 to 4 hours after a 50,000 IU oral dose,65 and then slowly returned to pretreatment suboptimal levels. Clearly this must disrupt normal feedback mechanisms in D and calcium regulation.

Vitamin A can be administered in large, infrequent doses from consumption of animal or fish liver (or injections, used in third world countries to prevent blindness) because we have storage capacity for vitamin A in our livers. Vitamin D is different. It has only a small storage pool in the liver and peripheral fat. Our ancestors most definitely did not get vitamin D in large, infrequent doses. While vitamin D is stored in body fat, storage is not sufficient to maintain optimum blood levels during winter months.78 A single exposure to UV-B light will raise levels of vitamin D over the next 24 hours and then return to baseline or slightly higher within 7 days. Historically our requirements for D were satisfied by daily exposure to sunlight and/or daily intake from food. Lowfat diets and lack of seafood in the diet further contribute to the current worldwide insufficiency of vitamin D.

Sunlight on the Inside

If any nutrient incorporates the properties of sunlight, it is vitamin D. The healthy "primitive" peoples that Dr. Price observed not only had broad, round, "sunny" faces, they also had sunny dispositions and optimistic attitudes towards life in spite of many hardships. Typical food intakes for peoples who have not been "civilized" range from 3,000 IU-6,000 IU. Modern intakes are paltry in comparison. The standard American diet provides vitamin D only in very low quantities.

The first step towards redressing some of the ills of civilized life—from depression to road rage, from cavities to osteoporosis—would be to get more light, inside or outside. Vitamin D adds sunlight to life from childhood through the golden years. In nonagenarians and centagenarians high levels of vitamin D in the blood and normal thyroid function were the strongest markers of health and longevity.79

Whether in the form of sunlight or dietary vitamin D from food and fish oils, optimal levels of the sunshine vitamin allow your body and mind to thrive, even during periods of stress.


Sidebar Articles

Food Sources of Vitamin D

USDA databases compiled in the 1980s list the following foods as rich in vitamin D. The amounts given are for 100 grams or about 3 1/2 ounces. These figures demonstrate the difficulty in obtaining 4,000 IU vitamin D per day from ordinary foods in the American diet. Three servings of herring, oysters, catfish, mackerel or sardines plus generous amounts of butter, egg yolk, lard or bacon fat and 2 teaspoons cod liver oil (500 iu per teaspoon) yield about 4,000 IU vitamin D—a very rich diet indeed!

Cod Liver Oil
Lard (Pork Fat)
Atlantic Herring (Pickled)
Eastern Oysters (Steamed)
Catfish (Steamed/Poached)
Skinless Sardines (Water Packed)
Mackerel (Canned/Drained)
Smoked Chinook Salmon
Sturgeon Roe
Shrimp (Canned/Drained)
Egg Yolk (Fresh)
(One yolk contains about 24 IU)
Butter
Lamb Liver (Braised)
Beef Tallow
Pork Liver (Braised)
Beef Liver (Fried)
Beef Tripe (Raw)
Beef Kidney (Simmered)
Chicken Livers (Simmered)
Small Clams (Steamed/Cooked Moist)
Blue Crab (Steamed)
Crayfish/Crawdads (Steamed)
Northern Lobster (Steamed)
10,000
2,800
680
642
500
480
450
320
232
172
148

56
20
19
12
12
12
12
12
8
4
4
4

The Many Forms of Vitamin D

There are two types of vitamin D found in nature. Vitamin D2 is formed by the action of UV-B on the plant precursor ergosterol. It is found in plants and in was formerly added to irradiated cows milk. Most milk today contains D3. Vitamin D3 or cholecalciferol is found in animal foods. Both forms of vitamin D have been used successfully to treat rickets and other diseases related to vitamin D insufficiency.

Many consider D3 the preferred vitamin, having more biologic activity. Vitamin D3 as found in food or in human skin always comes with various metabolites or isomers that may have biological benefit. Dr. Price believed that there were as many as 12 metabolites or isomers in the vitamin D found in animal foods. When vitamin D is taken in the form of fish oil, or eaten in foods such as eggs or fish, these metabolites will be present. Both D2 and D3 can be toxic when taken inappropriately in large amounts.

When humans take in vitamin D from food or sunlight, it is converted first in the liver to the form 25(OH)D and then in the kidney to 1,25(OH)D. These active forms of vitamin D are available by prescription and are given to patients with liver or kidney failure or those with an hereditary metabolic defect in vitamin-D conversion.


Assessing Vitamin D Status

Blood Testing: Currently there are two tests available for physicians to assess vitamin-D status. One is for the somewhat biologically active precursor 25(OH)D and another for 1,25(OH)D, the most active form, which is converted in the kidney and other organs. The latter is often normal in the blood even when the precursor 25(OH)D is low or deficient. The precursor is a better marker of vitamin-D status (or reserves) than the most active 1,25(OH)D form. It is the optimum level of 25(OH)D that is most strongly associated with general good health. (The test values given in this article are for 25(OH)D.) For many years the acceptable level of 25(OH)D has been at least 9 ng/ml (23 nmol/l). Some researchers believe that 20 ng/ml (50 nmol/l) should be the lower acceptable limit72 but Dr. Vieth presents a large amount of data to support his claim that this is far from optimal.3 Optimal levels are certainly at least 32 ng/ml (80 nmol/l) and preferably closer to 40 ng/ml (100 nmol/l).

Salivary pH Testing for calcium sufficiency: A method of assessing ionized calcium levels has been used by Weston Price, DDS and Carl Reich, MD and has confirmation in current research.73 After determining your serum-D status (testing) and undertaking a program of supplementation with vitamin D, calcium and magnesium, morning salivary pH should read 6.8-7.2. Lower values may indicate insufficient vitamin D (retest), or low levels of calcium in the diet. Look for pH paper with a range of 5.5-8.0 and increments of 0.2. PH papers with 0.5-degree increments are not sensitive enough to monitor progress. (Note: Do not take more than 1,000 IU of vitamin D without testing and supervision by a knowledgeable healthcare practitioner. Calcium can be adjusted within the ranges suggested. Several months of supplementation may be required to show positive results if the deficiency is severe and prolonged.)


Sources


References

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  4. Glerup H, Mikkelsen K, Poulsen L et al. Commonly recommended daily intake of vitamin D is not sufficient if sunlight exposure is limited. J.Intern.Med. 2000;247:260-8.
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Vitamin D Update, Winter 2000

Note: This update appeared in Wise Traditions in Food, Farming and the Healing Arts, the quarterly magazine of the Weston A. Price Foundation, Winter 2000.

Since the publication of "The Miracle of Vitamin D" in the last issue of Wise Traditions, some clarification is necessary. The action of vitamin D, whether from food, supplements or sunlight conversion, is that of a "pro-hormone," rather than of a vitamin.

According to the dictionaries, a hormone is a substance, usually a peptide or steroid, produced by one tissue and conveyed by the bloodstream to another. Hormones affect physiological activity, such as growth or metabolism. More generally, a hormone is one of various similar substances found in plants and insects that regulate development. By contrast, vitamins are various fat-soluble or water-soluble organic substances essential in minute amounts for normal growth and activity of the body. They are obtained naturally from plant and animal foods.

Hormones are powerful regulators that can have both good and bad effects. With progesterone, DHEA, estrogen, thyroid or any other hormone, including vitamin D, there can be a profound cellular response when levels are altered by supplementation. Vitamins and minerals are elements used by the body to make enzymes, bone, immune fractions and other substances in the human body, but they are not regulators.

As a pro-hormone, vitamin D can be dangerous because too much has the potential for great harm as does too little. That is why testing is important for those on vitamin-D therapy. When you take thyroid hormones, you are instructed to test first and retest to make sure the amount you are taking is correct. So, too, with vitamin D. The rule is test, treat (if necessary) and retest until you find the right amount to meet your daily need. According to our current levels of knowledge, there are no obvious symptoms of vitamin D overdose until the overdose is nonreversible. Testing can alert us not only to deficiency but also toxicity. Fortunately, we now have tests for vitamin D status that are not expensive.

In my practice, I am discovering that some people may need upwards of 4,000 IU daily to maintain optimal blood levels. Others may find that anything over 200-400 IU puts them in a situation of overdose. This is a problem of genetics. Some people utilize vitamin D better than others. Before the days of travel and great population migrations, the process of natural selection created population groups that best responded to the levels of vitamin D available through exposure to sunlight and in the diet. Migration, immigration and intermarriage make it impossible to determine needs without testing.

Once you test and determine the level of D from sunlight, food and supplements that maintains optimum levels of vitamin D in your blood, then you know the "dose" that you will need as long as you live at that altitude and latitude. You should test twice a year as in many locations the need for D may vary greatly from summer to winter.

For detailed information visit my website sunlightandvitamind.com


Vitamin D Update--A Warning, Fall 2002

Note: This update appeared in Wise Traditions in Food, Farming and the Healing Arts, the quarterly magazine of the Weston A. Price Foundation, Fall 2002.

I have reported in this magazine on the substantial benefits that can be gained from vitamin D therapy (Wise Traditions, Fall 2000). However, my own clinical experience and the research of others is clearly showing chronic subclinical vitamin D toxicity is possible, from both supplements or tropical sunlight. Elevated levels of serum vitamin D can cause significant bone loss and calcification of soft tissues.

If you are using supplements of vitamin D (natural or synthetic) or are light skinned and have had significant sun exposure in tropical or subtropical areas and haven't done so before, it is very important to test your blood levels of D.

Optimal values of 25(OH)D are 40-50 ng/ml
Acceptable values of 25(OH)D are 35-55 ng/ml
Levels above 55 ng/ml will be toxic for some individuals.

There is no good reason to maintain levels of D in this higher range and strong evidence showing potential harm.

You need to TEST. The correct test to order is 25(OH)D, also called 25-hydroxyvitamin D. Make sure this is the test you get. Labs often give the test for 1,25-dihydroxyvitamin D, the active hormone. This test is the wrong test as it offers no meaningful data regarding D status.

Lab One offers the least expensive testing I have found nationwide and is available in most states. Your physician can reach them at 1-800-646-7788. The test is 25-hydroxyvitamin D. The Lab One test number, just to be sure you get the right test, is #3247. Rarely does insurance cover the cost for this test, which is about $60 including lab fees. Other labs I have queried charge $100-180 for the same test.

The important thing to remember if you are doing vitamin D therapy, or spending lots of time in the sun, is to TEST!


Instructions for physician monitoring of vitamin D, calcium and magnesium repletion are available from www.sunlightandvitamind.com or by contacting Krispin at krispin (at) krispin.com or 1-415-488-9636.

This article appeared in Wise Traditions in Food, Farming and the Healing Arts, the quarterly magazine of the Weston A. Price Foundation, Fall 2000.

About the Author

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Comments (22)Add Comment
Mr
written by Fran Sanchez, Nov 28 2013
This is a great article. Vitamin D plays a very important role in the body. For example, it has been shown that Vitamin D is very important for us guys to produce testosterone. The right food and sunlight can go a long way.
Updated
written by D., Feb 05 2011
This article should be updated. It was written in 2000 and the values of the blood testing for Vit D have been raised. I don't remember where I read it but I think now the levels can be as high as 50-70% and still be well within normal limits.
...
written by Shary, Dec 30 2010
I had been dealing with chronic musculoskeletal pain for about 6 years. About a year ago I began supplementing with 4,000 IU per day of vitamin D3 and began to notice slow improvement. About a month ago, based on information put out by the Vitamin D Council, I increased my supplementation to 8,000 IU--yes, that's 8-thousand IU--per day, even though my 25-hydroxy blood level was already 35 ng/ml, which is considered by many doctors to be optimal. Within a couple of weeks the pain in my shoulders, hips and knees was almost completely gone and has stayed gone. I have also noticed considerable improvement in my balance and stability, decreased stiffness of joints, faster healing, and I have tons more energy. In fact, I feel better than I have in years.

Granted, 8,000 IU is high. I intend to drop back to the Council's recommendation of 5,000 IU per day in the next month or so. Come summer, as much as possible I plan to get my D from the sun, which is probably the best source.

I think research will eventually prove that what is "optimal" for some people is woefully inadequate for others. I also think that all this scaredy-cat wringing of hands over vitamin D toxicity will turn out to be flat-earth science.
@lex
written by ryan, Dec 18 2010
As with food, nature is where we should look to for health. The sun has been there since life began on this planet and it is utterly silly to think we can improve upon it any more than we can improve upon food. I fail to see where you risk overexposure chasing the sun. In most cases it's a simple matter of getting in the shade, and/or putting on long sleeves and/or a hat. Furthermore, like our food is more than just a few vitamins and minerals, sunlight contains a lot more than just uv a and uv b, and we don't know what other benefits we would miss out on if we were to stop solarizing! Nothing wrong with using technology when absolutely necessary, but if it can be avoided we are all the better for it. Naturally this is IMO, take it or leave it.
sources of vitamin d
written by Sandra, Oct 26 2010
Vitamin D is an immensely important nutrient to human health. It plays a part in a variety of bodily maintenance, by regulating calcium levels, contributing to a strong skeleton, and aiding the immune system in its battles against harmful intrusions. Deficiency in vitamin D can contribute to many illnesses and problematic conditions. Luckily, sources of the essential nutrient are easily found, as it is present in many different forms.
http://www.healthywomenguide.c...min-d.html
Vit D and Sarcoidosis
written by LD, May 01 2010
I have sarcoidosis and it acquiesed (dormant) I am also D Deficient, I was prescribed Vit D 1 a week for 4 weeks,I read I should not take Vit D if sarcoidosis is present, my question is, is it okay to take Vit D with the sarcoid being in a dormant stage?
...
written by Lillian Hewitt, Apr 30 2010
my dr has just told me im vitamin d diff....# 19 so he has ordered d by mouth for 8 weeks.. whats the side effects with pain meds... endacent.. lyrica ?
n/a
written by Jerry, Apr 25 2010
My internist reads about disease, I read about health. So I had to talk him into giving me a Vitamin D blood test. It was a mere 34 (2 above the lower limit) and he said "That's OK, it's within normal limits" (30 to 100). I said I didn't want to be at the lower end of the scale. He reluctantly gave me the 50,000 pills weekly and in two months my blood sugar dropped to a normal 95 from its chronic pre-diabetic 105 and my D levels rose to 68. I had been only able to get it to 45 by taking 2000 daily D3 supplements. I always take it with a CA, Mg, and Zn pill and read now here that that should be spread out during the day. Now my doctor warns me of cardiac calcification, heart attacks in elderly women from calcium supplements, and I read somewhere about pancreatic side effects. I have to go find those studies. p.s. the pharmacist should know if the magic green pill is D2 or D3.
response to "altmed" post
written by Terra, Apr 20 2010
I just wanted to let you know that I too am taking a vit. D supplement of 50,000 UI once per week. I take a green pill with "PA-140" written on the side. This is a prescription for ergocalciferol which is another word for "D2". If you want "D3" you need to look for cholecalciferol which,I believe,is available OTC. I know my sister-in-law works as a pharmacy tech and she says that she is almost positive that all prescriptions for vit. D supplement are D2. I have found a brand called "maximum D3" which is D3 in health food stores.

On a personal note though, I would advise against buying a large quantity of 50,000 UI's because I'm sure once you get to a more normal range of vit d, your dosing will go down. Your doctor will probably be monitoring your blood levels (like mine is) and will use that in calculating future dosages. Like the article states, too much vit. D can be toxic and should always be monitored, especially when taking such large quantities. I'm only a medical assistant and not a doctor, so this is only my opinion. Please ask your doctor for further information as he/she is probably able to give a more accurate statement.
good lucksmilies/smiley.gif
Prescription vitamin D
written by Jodi, Apr 19 2010
I've read that all prescription vitamin D is D2, the wrong form of vitamin D. 'The Vitamin D Cure' book says to ditch the script and buy plain D3 from any shop!

ps. I have just read a ton on vitamin D, and most articles seemed to se the optimum level was 50 - 70 ng/ml or 50 - 80 ng/ml so I am wondering why there is such scariness expressed here at levels withion this range??
Vitamin D or A and Fluorescent light bulbs
written by Leilani M., Apr 18 2010
Thanks for your work! I read years ago in Adelle Davis about the dangers of the fluorescent light bulb causing vitamin deficiencies in the work place. Does this relate to Vitamin D as well as Vitamin A? Is the highly promoted, but fluorescent, "spiral" energy efficient light bulb capable of causing deficiencies the same as the standard fluorescent bulb?
R.N.
written by Elena, Apr 12 2010
Thank you Krispin and WAPF for this fantastic article! Very clear, very helpful and well researched. Isn't it amazing and so sad that the doctors tell us about vit. D defficiency but are unable to provide guidance on how to correct it? Sigh! Medical education really has to change before the noble proffession of a medical doctor loses is credibility completely with people... Bravo to the docs who think outside of their inadequate schooling and respect the wisdom and the traditions of our ansestors, - you truly are the cream of the crop! Thank you all who are taking responsibility for your health and making the world a more aware, healthier place!smilies/smiley.gif
OUCH! Prescription D is expensive! What type is it? D3? & other questions!
written by Altmed, Apr 11 2010
Great article!

The tanning bed issue seems ridiculously overstated in recent news (I used to use them in the winter in S. CA. Not because of any test, but because I felt better when I did use them, and my tan was wonderful too! I've never been to a tanning salon that will allow you to go in for very long the first few times without testing you, and I have been to many!)

The hype in the media re: OMG! Sunlight is so bad for you! Is simply ridiculous, sells a LOT of products, keeps a lot of us out of the sun at all, unless having masses of sunscreen on! Then OMG Many, MANY of us have vitamin D deficiencies, and the pharma & medical industry has over and over taught those who work in the field that sunlight = death (thankfully many know better!)
my D levels are reportedly low & my rheumatologist put me on 50,000 IUs once a week. Interesting too, when I filled the prescription, it simply says "Vitamin D", but doesn't tell me which type.

I can get 50,000 IU capsules of D3 FAR less expensive than the prescription dose... For what I paid for 3 green gel caps that say PA150 on the side of the gel cap, I could have bought about 150-200 D3 capsules of the same dose (50,000 IUs) for that price, and if needed, likely will in the future!

So, why don't we get more than "Vitamin D" on the label of a prescription Vitamin D? 3 capsules were close to $30!!! (came up to about $9 a capsule), so I have to wonder why it cost me so much???


Anyone have any idea what form of Vit. D is used in this prescription? Green gel cap says PA 140 on the side, & label says made by Breck? Seems like this is likely a ridiculous rip-off and I could buy it, even in the same pharmacy OTC for a WHOLE lot less!

Took the first dose yesterday... OK thus far... no noticeable changes yet.

Also, I wonder if this deficiency could explain extreme eye photosensitivity over the years?

I too think its interesting how this "low fat nation" is getting less & less healthy & eating more & more carbos & wonder why with so much altered food why we've become by and large a very unhealthy nation!?!

We need to get back to natural foods, sunshine & exercise!

D deficiency
written by Amber Gardner, Apr 07 2010
I'm 28 and was diagnosed with low D. I've been suffering for years and my bones are soft. My skeleton does not do it's job. They have me taking 50,000 IU's 3 times a week for 3 weeks, and then down to 50,000 a week. It's amazing to me that all of this trouble could be caused by a VI TA MIN.
50,000once a week
written by Debra, Apr 03 2010
I feel very sleepy and MORE down a couple hours after taking my once a week "D" . I have only taken it twice so far~ IT does help my 4 months of insomnia tho' . Does anyone else feel like they have a cotton brain after taking the 50,000?
Thank you for this article
written by SIck & Curious, Apr 02 2010
I was recently tested, found deficient in Vit. D intake and was prescribed a treatment of 50,000 IUs once a week for 8 weeks. I'll update when I am through with the treatment. My post though is more to say that IF this is true, I am pretty livid that no other doctor throughout the years ever made this connection with me. All the lab work, etc., that I have been through for many of the symptoms listed for Vitimin D deficiency and not one thought to test for this? Is this not one of the routine tests? Do they get kickbacks from prescribing pharmacuetical drugs rather than just testing first for vitimin (any vitimin) deficiency, or do they not all know this?
Query
written by Will Q, Mar 25 2010
Hello everyone/anyone,

The USDA has a website which gives the nutritional breakdown of nutrients based on quantity. http://www.nal.usda.gov/fnic/foodcomp/search/ This site reports different levels of Vitamins (generally less) than this article sites. Can anyone account for this discrepency (I noticed that lard and sardines were particularly different than the levels noted in this article, but the cod liver oil, for example, was spot on).

Cheers,

Will
Interaction with Meds
written by Susan Tupa, Mar 16 2010
Is there any interaction with diabetic and cardiac medication?
...
written by Ines, Mar 16 2010
Thank you for all this information.

I wish you could have a list of practioners by state that are aware of the importance of vitamin D. When I tell my doctors that I have low level of vitamin D they seem to be careless (and surprise that I mentioned)
I will be the first one to read the new book your are writing about fertility, pregnancy, etc..smilies/kiss.gif thank you!
...
written by lex, Mar 05 2010
great article. well researched and well written, very informative. One slight error. Tanning lamps do have enough UVB in them and is a perfect , and most efficient way to help the body produce optimum levels of vitamin d instead of chasing the sun and risk overexposure and burning due to alot of guesswork involved. Tanning lamps are FDA and CSA approved. The media has twisted the truth. It is not that the tanning lamp is bad. It's that it can be bad if used incorrectly. Big difference. I wouldn't expect you to jump and advertise for tanning industry since you dont benefit, but it is responsible to at least point out an unescapbale truth. Indoor tanning, if performed responsibly, is a great source of vitamin d ( Health Canada also states and lists tanning beds as a source). Thank you
Deficient
written by ThursdaysAngel, Mar 03 2010
Fantastic article! I have been researching this pretty extensively because my Dr. said I am deficient in Vitamin D. My first results were Total Vitamin D - 14 and Total D2 -
...
written by Victoria, Feb 27 2010
Wow! Thanks for a great article, "The Miracle of Vitamin D". Your article was by far the best I found on the subject. I was just told I have a deficiency (9 on the blood test.) I'll use this data to supplement wisely between now and my next test. Thanks again!

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Last Updated on Monday, 30 May 2011 19:19