Page 44 - Spring2013
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Adequate         vegetarians are twice as likely and vegans are  is six times richer.  Thus, most omnivores may
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                              three times as likely to have elevated homo-  stand to gain substantial improvements in mental
           glutathione  cysteine.  Figure 5 provides a resolution to this  health by including glycine-rich skin and bones
                                     15
                   status     paradox: while vegetarians and vegans may  (in the form of bone broth) in their diets.
                              generate less homocysteine, they also have lower     Moreover, Figure 5 shows that folate assists
                protects  intakes of vitamin B , which is needed to recycle  vitamin B  in its support of the methylation pro-
                                                                                 12
                                               12
                  against     homocysteine back to methionine.           cess. Folate is found primarily in legumes, leafy
                                  Indeed, using the highest quality markers  greens and liver. Vegetarians tend to consume
         degenerative  of vitamin B  status, investigators have esti-    more leafy greens and legumes than omnivores,
                                         12
       diseases of all        mated that up to 73 percent of vegetarians and  and most omnivores fail to take advantage of
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                   kinds.     up to 90 percent of vegans are deficient in B .   liver or other organ meats. Many omnivores may
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                              This should be unsurprising since vitamin B  is  thus improve their mental health even further by
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                              found almost exclusively in animal products, and  including folate-rich plant foods and liver in their
                              even that which occurs in eggs, a key vegetarian  diets.
                              source of animal protein, is poorly bioavailable. 16
                              Thus, methylation takes a double-whammy: less  HARNESSING GOOD NUTRITION
                              methionine is available to begin with, and what  FROM ALL SOURCES
                              is available often gets trapped as homocysteine     Vegetarians and  vegans  may  adhere
                              rather than being recycled.                more strongly than omnivores to other health-
                                  Figure 5 provides another key part of the  promoting habits as well. This is especially
                              balance. When methionine concentrations rise,  important to consider if we are interested in
                              for example after eating a protein-rich meal, the  preventing all diseases rather than just mental
                              amino acid glycine acts as a buffer to prevent  disorders. For example, Figure 5 shows that
                              excessive methylation. Although animal foods  glycine helps convert homocysteine to gluta-
                              are not richer in glycine than plant foods as a  thione, the master antioxidant and detoxifier of
                              proportion of total protein, a diet that includes  the cell, and a key regulator of protein function.
                              animal products provides more glycine than one  We might predict from this that vegetarians and
                              that does not simply because it is richer in total  vegans should have lower glutathione status than
                              protein.                                   omnivores because of lower intakes of methio-
                                  Vegetarians excrete almost twice the level  nine and glycine.
                              of a unique marker of glycine deficiency in their     Some studies, however, have shown that
                              urine as omnivores.  This suggests that exclud-  while vegans have lower glutathione status than
                                               17
                              ing animal products from the diet could not only  omnivores, vegetarians have slightly higher glu-
                              lead to a generally inadequate level of meth-  tathione status.  Unlike the vegans, the vegetar-
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                              ylation because of lower intakes of methionine  ians in such studies may have been consuming
                              and vitamin B , but the lower intake of glycine  plenty of milk and eggs. Thus, the vegetarians
                                          12
                              could also lead to transient periods of excessive  and omnivores may have had similar intakes of
                              methylation. This could theoretically result in  methionine and glycine. Both the vegetarians and
                              seesawing between excessive mental stability  vegans may have been consuming more fruits
                              and excessive mental flexibility.          and vegetables. These provide vitamin C, which
                                  The purpose of this article, however, is not  spares glutathione from oxidation, polyphenols,
                              to denigrate vegetarian diets but to emphasize  which increase the production of glutathione,
                              the importance of nutrient-dense animal foods.  and, especially in their raw state, glutathione
                              A standard omnivorous diet is hardly the ideal.  itself.
                              Even omnivores excrete substantial amounts of     Adequate glutathione status protects against
                              the marker of glycine deficiency discussed above  degenerative diseases of all kinds. The best way
                              in their urine.  This could be because the typical  to support glutathione status would likely be to
                                         17
                              omnivore fails to make use of skin and bones in  consume a traditional diet that includes plenty of
                              their diet. Protein from skin is three times richer  nutrient-dense foods of all kinds: meat, organs,
                              in glycine than meat, while protein from bones  bones, skin, folate-rich legumes and leafy greens,
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