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          two, will strengthen the immune system; but if it  lori correlated inversely with allergic disease. It
          arrives late, it appears “to strengthen aggressive  may also protect against autoimmune diseases
          tendencies,” aggression that may turn against the  “. . . insofar as the bug elicits damaging inflam-
          self (page 204). Some optimistically envision an  mation, it will worsen health. But to the degree
          EBV vaccine to eradicate MS. Or, should we take  that it strengthens immune regulation, it will
          the other tack and try to work with nature rather  prevent diseases of immune dysregulation. It
          than against her? After all, manmade antibiotics  can do both” (page 161). Here is more argument
          before age one result in 50 percent more asthma,  against using antibiotics recklessly—and away
          according to a survey of twenty studies.   with hand sanitizers!
              Velasquez-Manoff definitely has a way     Back to autoimmunity. If you have one of
          with words. Consider this: we have “a genome  these diseases, you might be willing to try a
          dramatically sculpted by worms” (page 94). All  dose of hookworm. The author did. He was ad-
          those prehistoric wormy sculptors predisposed  ditionally motivated by the prospect of having
          mankind to our current immune responses, one  a child and wondered about the genes he might
          of which is immunoglobulin E, an antibody  be handing on. I will leave it to you to read his
          formerly kept occupied by the hookworm.  story and those of others who have thus infected
          However, the better equipped you are to cope  themselves to varying degrees of satisfaction.
          with hookworm, the worse your allergies will  The microbes and parasites in question kept the
          be when you don’t have it. As with allergies, so  immune system busy, so it didn’t cause trouble
          with asthma. Researchers have found a consis-  or engage in “friendly fire” against the self. You
          tent inverse relationship between asthma and  will find in the hookworm underground chapter a
          hookworm infection. “By subverting the host’s  website to investigate online. Barring that, what
          immune response, worms prompted tolerance  else should you do? Avoid alkalizing the skin
          to third party proteins. Hookworms incidentally  with soap and keep proteins away from inflamed
          taught people to tolerate dust mites” (page 87).  skin: remember the peanut oil in the diaper rash
          Blood flukes might help, too, but there’s a catch.  cream. Avoid the antibacterial, antifungal chemi-
          Too heavy a worm load and your defenses may  cal triclosan. Visit a cowshed or a pigpen with
          not be able to handle bacterial or other health  your baby. Drink unpasteurized milk. Avoid
          challenges and you will suffer as a result.  central air conditioning.
              Once again, Nature shows us the value of     Here you will find an intelligent, detailed,
          moderation and balance. Too much hookworm  eye-opening, and indeed fascinating account of
          or too little? Similarly, you can have too much  recent research into the links between parasites
          Helicobacter pylori, leading perhaps to ulcers  and immune problems. However, I’m disap-
          and stomach cancer, but, if you don’t have enough  pointed that Lyme disease is not even mentioned.
          you will be prone to asthma. This particular  Could it be that this East Coast scourge will
          bacterium—which resides in all of our stom-  have its silver lining? If we carry some of those
          achs—comes in varying degrees of virulence.  spirochetes around will we be less prone to al-
          There is one strain that, more than others, pre-  lergy and auto-immune diseases? Apart from   Once again,
          disposes us to stomach cancer. What else does  that, I recommend this book to anyone motivated
          H. pylori do? It helps regulate stomach acidity  enough to dig in. I haven’t even mentioned the  Nature shows
          to protect itself from competitor bacteria and,  chapters on autism or inflammatory illnesses like   us the value
          coincidentally, reduces our chances of GERD,  cancer and heart disease. There is a lot of meat   of moderation
          gastro-esophageal reflux disease. In a very big  here for any reader to chew on.
          epidemiological study called NHANES, H. py-                      Review by Rosalind Michahelles and balance.
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