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grateful to the researchers, fat-soluble experts, nutritionists, holistic 16. Hiraike H et al. Distribution of K vitamins (phyllo-
doctors, farmers and the people taking their emu oil who have shared quinone and menaquinones) in human placenta and
their experiences with it. If you would like to share your experience or maternal and umbilical cord plasma. Am J Obstet
Gynecol. 1988 Mar;158(3 Pt 1):5649. https://www.
learn more about this vitamin K MK-4 resource, call (715) 305-2526 or ncbi.nlm.nih.gov/pubmed/3348316.
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visit walkabouthealthproducts.com. 17. Emanus N et al. Vitamin K2 supplementation does
not influence bone loss in early menopausal women:
REFERENCES a randomized double-blind placebo-controlled
1. Dam H. The Discovery of Vitamin K, Its Biological Functions and Therapeutical trial. Osteoporos Int. 2010 Oct; 21(10):1731-40. doi:
Application. Nobel Lecture 1946. NobelPrize.org. Nobel Media AB 2020. Wed. 10.1007/s00198-009-1126-4. Epub 2009 Nov 25.
11 Mar 2020. https://www.nobelprize.org/prizes/medicine/1943/dam/lecture/. 18. Iioka H et al. Pharmacokinetics of vitamin K in moth-
2. Price WA. Nutrition and Physical Degeneration. La Mesa, CA: Price-Pottenger ers and children in perinatal period: transplacental
Nutrition Foundation, 1939. transport of the vitamin K2 (MK-4). Asia Oceania
3. Conreras S. Menadione (vitamin K3). The Dog Food Project, 2004; www.dog- J Obstet Gynaecol. 1991 Mar; 17(1):97-100.
foodproject.com. 19. Iioka H et al. A study on the placental transport
4. Schugers LJ, Vermeer C. Determination of phylloquinone and menaquinones in mechanism of vitamin MK2 (MK-4). Asia-Oceania
food. Haemostasis 2000;30:298–307 https://doi.org/10.1159/000054147. J Obstet Gynaecol. 1992;18(1): 49-53. www.ncbi.nlm.
5. VitaK Laboratories. Form 11.1: Result from Vitamin K measurements (Weston nih.gov/pubmed/1627060.
A. Price Foundation, June 2015). minKMeasurements120315-WestonPriceFoun- 20. Iioka H et al. Characterization of human placental
dation-foodsamples1. activity for transport of vitamin K2 (MK-4) us-
6. VitaK Laboratories. Form 11.1: Result from Vitamin K measurements (Weston ing syncytiotrophoblast brush border membrane
A. Price Foundation, November 2015). minKMeasurements021015-WestonPrice- vesicles. 1992 A-26. Placenta 2002.https://www.
Foundation-foodsamples. placentajournal.org/article/0143-4004(92)90113-8/
7. VitaK Laboratories. Form 11.1: Result from Vitamin K measurements (Weston pdf.
A. Price Foundation, April 2015). minKMeasurements120315-WestonPriceFoun- 21. Nakagawa K et al. Identification of UBIAD1 as a
dation-foodsamples. novel human menaquinone-4 biosynthetic enzyme.
8. Walther B, Chollet M. Menaquinones, bacteria, and foods: vitamin K in the Nature 2010 Oct; 468, pages 117-121(2010)
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diet. Vitamin K - vital for health and wellbeing, Jan 2017, Oxholm Gordeladze, 22. Kim KA, et al. Mechanism of menadione-induced
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IntechOpen, DOI: 10.5772/63712. cytotoxicity in rat platelets. Toxicol Appl Pharmacol.
9. Komai M, Shirakawa H. Vitamin K metabolism. Menaquinone-4 (MK-4) forma- 1996 May;138(1):12-9. PMID: 8658500.
tion from ingested VK analogues and its potent relation to bone function. Clinical 23. Collins F. Study finds no benefit for dietary supple-
Calcium, Dec. 2007, 17(11):1663-72. ments. NIH Director’s Blog. 2019 Apr 16; https://
10. Vitamin and mineral requirements in human nutrition. Report of a Joint FAO/ directorsblog.nih.gov/2019/04/16/study-finds-no-
WHO Expert Consultation. World Health Organization and Food and Agriculture benefit-for-dietary-supplements/.
Organization of the United Nations, 2004 ISBN 92 4 154612 3. 24. Chatron N et al. Structural insights into phylloqui-
11. Matius C. [About the change from vitamin K1 to vitamin K2, MK-4 in the animal none (Vitamin K ), menaquinone (MK4, MK7),
1
body]. Uber die Umwandlung von Phyllochinon (Vitamin K) in Vitamin K2(20) and menadione (vitamin K3) binding to VKORC1.
im Tierkorper. Biochem. Ztschr., 333:430, 1960. Nutrients. 2019 Jan 1;11(1). pii: E67. doi: 10.3390/
12. Martius C. [Studies on the transformation of the K vitamins given orally by ex- nu11010067.
change of side chains and the role of intestinal bacteria therein]. Biochem Z. 194 25. Leichhardt L. Journal of an overland expedition in
Aug 11; 340:290-303 PMID: 14317959. Australia -From Moreton Bay to Port Essington, a
13. Davidson RT et al. Conversion of dietary phylloquinone to tissue menaquinone-4 distance of upwards of 3000 miles, during the years
in rats is not dependent on gut bacteria. J Nutr. 1998 Feb;128(2):220-3. 1844-1845. T. and W. Boone London, 1847. Epub
14. Ronden J et al. Intestinal flora is not an intermediate in the phylloquinone- mena- 2002, University of Sydney Library. http://setis.
quinone-4 conversion in the rat. Biochimca et Biophysica Acta (BBA) - General library.usyd.edu.au/ozlit/pdf/p00050.pdf.
Subjects. Volume 1379. Issue 1, 8 January 1998, p. 69-75. 26. Bennett DC, Coe WE, Godin DV, Cheng KM. Com-
15. Komai M, Shirakawa H. [Vitamin K metabolism. Menaquinone-4 (MK-4) forma- parison of the antioxidant properties of emu oil with
tion from ingested VK analogues and its potent relation to bone function]. Clin other avian oils. Aust J Exp Agr 2008; 48(10) 1345.
Calcium. 2007 Nov;17(11):1663-72. https://doi.org/10.1071/ea08134.

SIDE EFFECTS OF SYNTHETIC VITAMIN K
When taking K MK-7 supplements, patients report allergic reactions, anxiety, insomnia and heart palpitations,
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which were resolve when they stop taking it.
“I had to quit taking the K MK-7. It was causing extreme arrhythmia.”
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“We tried three different brands of synthetic K : two different MK-7s supplements and one synthetic MK-4. My
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wife had the same reaction to all of them, a bad skin rash, severe anxiety and heart pounding. We know it was the
supplement because she didn’t change anything else.”
These experiences make it very clear: we need to get our vitamin K from food!
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