Japanese Journal of Clinical Oncology, Volume 44, Issue 9, September 2014, Pages 777–782
Patients responded to a question survey according to their dietary habits and been followed for vital status and the occurrence of cancer and other diseases. “We have tested the association between potential causal factors and the incidence of or mortality from cancer and other diseases…” Studies stating their typical dietary intake of low nutritional value in Japan mentioned are high consumption of soy/isoflavones,…”
Endocrinology, Volume 156, Issue 10, 1 October 2015, Pages 3466–3472; Jente Stel & Juliette Legler
Recent researchers found soy isoflavones similar to infant formula fed on mice plays a role for exposure to endocrine-disrupting chemicals (EDCs) in the obesity epidemic. “Obesogenic EDCs have the potential to inappropriately stimulate adipogenesis and fat storage, influence metabolism and energy balance and increase susceptibility to obesity.”
Yu J, Bi X, Yu B, Chen D. Isoflavones: …possible caveats. Nutrients. 2016;8(6):361.
study discovered that exposure to soy-based infant formula resulted in negative effects on the long-term development of infants.
Toxicol Appl Pharmacol. 2016 Feb 15; 293: 53–62.
Study shows in rat model a negative effect(s) of thesex organs by their intake of soy (genistein). The inhibit of follicle, disrupts the production of sex steroid hormones, and alters the expression of steroidogenic enzymes. Like other phytoestrogens found in soy, this has the potential to mimic, enhance, or impair the estradiol pathway, thereby altering ovarian follicile growth.
Nutrients. 2016 Dec; 8(12): 754: Mark Messina
Soy isoflavones have a tendency to mimic hormone estrogen. Because of the soybeans biological active molecules, this causes trouble especially with women on menopause.
Nutr Res. 2016 Aug; 36(8): 827–834.D
Data shows that there is a link between long term soy consumption and Kawasaki disease (KD). Soy isoflavones play a role in this.
Patisaul HB. Endocrine disruption by dietary phyto-oestrogens: Impact on dimorphic sexual systems and behaviours. Proc Nutr Soc 2017;76(2):130-44.
“Consumption by infants and small children is of particular concern because their hormone-sensitive organs, including the brain and reproductive system, are still undergoing sexual differentiation and maturation. Thus, their susceptibility to the endocrine-disrupting activities of soya phyto-oestrogens may be especially high.”
Jessica Pasley; National Institute of Environmental Health Sciences (NIEHS), & epidemiologist at Monroe Carell Jr. Children’s Hospital at Vanderbilt; 2018
Early-life exposure to genistein, a naturally occurring component in soy formula, interferes with development of the reproductive system and changes in tissues that persist into adulthood, some may be related to menstrual pain.
Front Nutr. 2018; 5: 110; ID: 30533415Ilaria Testa, and others
Study found infant formula had negative effects on animals; including sexual development and reproductive function, neurobehavioral development, immune function, and thyroid function. This brought awareness associated with relevant abnormalities in children with congenital hypothyroidism.
Anne S Mallienet al.J Am Assoc Lab Anim Sci.2019.
Studies found the Soy isoflavones containing animal diets resulted behavioral issues. This influences estrogen-regulated systems, as well as dominating behavior and cognition.
Yang J, Wen L, Jiang Y, Yang B. Natural estrogen receptor modulators and their heterologous biosynthesis. Trends Endocrinol Metab 2019;30(1):66-76.
A change in gender-related behavior in children and feminization associated with soy consumption. In animals, the excessive PhE intake leads to derangements of fertility, sexual development and behavior. PhE are called modulators or disruptors of the endocrine system.
Journal of AOAC INTERNATIONAL, Volume 89, Issue 4, 1 July 2006, Pages 1207–1214; Chao Wu Xiao and others.
Several studies have shown that bioactive ingredient in soy changes the expression in several cell receptors of different tissues and cancer cells. Therefore, consumption of soy isoflavones disrupt endocrine functions, such as thyroid function and reproductive performance, (because of their similar structure to estrogens). Furthermore, changing their gene expression, stimulates the sensitivity of cells or tissues to the affects of physiological functions, such as growth, development, osteogenesis, immune response, lipogenesis, reproductive process, and anticarcinogenesis.
Norie Sawada and others nternational Journal of Epidemiology, Volume 49, Issue 5, October 2020, Pages 1553–1561
A study has shown that high intake of soy and isoflavones increased the risk ofprostate cancer. “During 16.9 years follow-up, we registered 221 deaths from prostate cancer. Isoflavones and soy products intake was associated with an increased risk of prostate cancer death.”
Minami Hatonoet al.Breast Cancer Res Treat.2021 Jan;185(2):307-316.
Studies say the metabolites of the soy isoflavones play a risk of development and recurrence of breast cancer and its interactions with drugs used for treating breast cancer.
36: 556-562 IOANNIS BOUTAS, ADAMANTIA KONTOGEORGI, CONSTANTINE
DIMITRAKAKIS and SOPHIA N. KALANTARIDOU; Kapodistrian, and others…
Third department of obstetrics and gynecology. National and kapodistrian University of Athens, Attikon Hospital, Athens, Greece; First Department of Obstetrics and Gynecology,National and Kapodistrian University of Athens, Alexandra Hospital, Athens, Greece
Collected data for over a decade from all around the world, showed an increase of women diagnosed with breast cancer. A case reported on the amount of isoflavone consumption and risk of breast cancer diagnosed in population, the result was 77.5% (7,209) were diagnosed.
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