Joe Rogan Experience #2420 – Chris Masterjohn

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Joe Rogan Experience #2420 – Chris Masterjohn
Uploaded by Powerful JRE (Nov. 29, 2025)
https://www.youtube.com/ watch?v=QBn54YNnKD0

Congratulations to Dr. Chris Masterjohn for scoring the big interview with Joe Rogan. Many of our members will recognize the name. Masterjohn has contributed many articles to our journal and spoken at several conferences.

The YouTube version is about two hours and twenty minutes, so the conversation covers a wide range of subjects, as you might imagine. One item that Rogan and Masterjohn spend some time on is methylene blue. What is that? Harvard describes it as one of the world’s oldest “organic dyes.” In recent times, it has gained a reputation for enhancing mitochondrial ef­ficiency. Masterjohn explains that it might help with certain very specific mitochondrial issues, but otherwise, it is likely to do more harm than good. You don’t want to mess with that stuff unless you know exactly what you are doing.

A recurring theme is “food first, pharma last.” Food should also come before supple­ments. If you need more CoQ10, for example, it is much better to get it from food than a supplement. According to Masterjohn, the best source of CoQ10 is heart. He makes the point that it is best to consume animal protein from nose to tail. Don’t just eat beef muscle meat; eat a proportional amount of heart, liver, kidney and other organ meats. Supplements are not a substitute for a bad diet. Again, you need to really know what you are doing. We often get questions at WAPF asking us what exact quanti­ties of food or supplements to take. Everyone is different. There is no one-size-fits-all formula. This podcast makes the point well.

Rogan asks why some experts claim seed oils are not a problem, while other experts dis­agree. It depends on what studies you are look­ing at. A number of studies run for only twelve weeks or less—these studies will not reveal any useful information. Cell damage can take eight years or more to accumulate, so experts who look at longer-term studies see a clear dif­ference between those who consume seed oils and those who don’t. This provides some good insight into how you can cheat on studies to get the results you want.

Masterjohn explains why there is a financial incentive to do short studies as opposed to lon­ger ones. If you have ever looked at published research, you will often notice that somewhere the authors will say, “more studies are needed” (translation: “gimme more money”). (I could also argue that it means, “this study wasn’t very well done,” but I’m sure I’m not supposed to think that or say it out loud.) The opportunity to make a play for more money obviously comes sooner and more frequently with shorter studies.

Masterjohn has a history of being excep­tionally good at tracking down all the studies on a given subject, smoking out any flaws and sorting out what it all means. That is on full display in this video, and the thumb is UP.

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